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Keep an eye on Carefully (1)pentobarbital will lessen the level or result of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lower in fentanyl plasma concentrations, insufficient efficacy or, possibly, development of a wi